CBDVA (cannabidivarinic acid) is the raw acid form of CBDV (cannabidivarin) found in living cannabis, and it doesn't intoxicate. Heat decarboxylates CBDVA to CBDV, and that chemistry is Established. What the acid does in people is a separate question: nobody has published a controlled human study of CBDVA, so it is untested rather than tested and null, and everything beyond the chemistry is catalogue in progress.
C20H26O4 · MW ≈ 330.42 · CAS 31932-13-5 · non-intoxicating raw acid · acid of CBDV · decarboxylates to CBDV (near-complete 130 °C / 30 min, verified) · from the varin mother acid CBGVA
Forms from CBGVA. Becomes CBDV.
40 questions, and 23 of them earn a verified grade on the six-rung evidence ladder. 13 carry an evidence state instead of a rung, and most of those read no primary evidence: our registry has no study on the question, a different finding from not supported and marked differently. The other 4 use an author qualifier still waiting to enter the controlled vocabulary. They appear without a grade chip until it does, rather than wear a guessed one.
CBDVA sits one heating step away from CBDV, a cannabinoid that has been through clinical research without establishing efficacy. The acid itself has never been tested in a controlled human study, and that gap is where most of the confusion on the shelf begins. Its chemistry is settled and graded as fact: what CBDVA is, its formula and CAS number, how the plant makes it, the heat that turns it into CBDV, and a raw acid that doesn't get anyone high. Anything said about effects or benefits is reported as a claim made by others, set beside its limits, and CBG Atlas does not make, adopt, or affirm these claims. Where the evidence runs out, we call it "catalogue in progress." Not medical or legal advice.
CBDVA (cannabidivarinic acid) is the raw acid form of CBDV (cannabidivarin) found in living cannabis, and it doesn't intoxicate. Heat decarboxylates CBDVA to CBDV, and that chemistry is Established. What the acid does in people is a separate question: nobody has published a controlled human study of CBDVA, so it is untested rather than tested and null, and everything beyond the chemistry is catalogue in progress.
Cannabidivarinic acid: the carboxylic-acid ("-ic acid") form of cannabidivarin (CBDV), itself the varin (propyl) homolog of CBD. The "A" marks the acid group the living plant makes first. Formula C20H26O4, molecular weight ≈ 330.42, CAS 31932-13-5. The name records Established chemistry and promises nothing about effects.
From the varin branch of biosynthesis. A synthase enzyme converts CBGVA, the varin "mother acid", into CBDVA, mirroring the way CBGA gives rise to CBDA on the main pentyl line. Heat then decarboxylates CBDVA to neutral CBDV.
Yes. CBDVA occurs naturally in raw, unheated cannabis, particularly varin-rich chemotypes, as the form the living plant makes; neutral CBDV mostly appears once heat, drying or ageing strips off CO₂. Labs can prepare CBDVA as a reference standard, but the molecule in hemp comes from the plant, as a matter of Established plant chemistry.
No. CBDVA is a raw cannabinoid acid, and those acids leave the CB1 receptor unactivated where THC switches it on. CBDV, which CBDVA becomes on heating, doesn't intoxicate either, and the record holds no verified case of CBDVA producing a high in people.
CBDVA isn't known to intoxicate, and neither is CBDV, its heated form. Whether the raw acid has some subtler psychoactive effect has never been studied, which leaves it open rather than ruled out. Controlled human data on CBDVA are missing in both directions, so that part of the question remains catalogue in progress.
Its effects in the body are not established. The one verified in-vitro finding for cannabinoid acids as a class is inhibition of the enzyme DAGLα (De Petrocellis 2011, PMID 21175579), a cell-level result, not an effect in people. Catalogue in progress.
What raw CBDVA does in people is unverified. It is a non-intoxicating acid with no established activity of its own, and for all the enthusiasm around "raw cannabinoids", CBDVA's raw effects are not established (not medical advice). Getting neutral CBDV takes heat to decarboxylate the acid. Catalogue in progress.
That depends on where the CBDVA came from and where you are; the molecule alone settles little. Where hemp-derived cannabinoids under 0.3% Δ⁹-THC are allowed, CBDVA generally falls inside that framework, and elsewhere it may be restricted. A general snapshot, dated 2026-07-11; not legal advice. Verify locally.
Generally yes, within one limit. Under the 2018 Farm Bill, hemp-derived CBDVA in a product at or below 0.3% Δ⁹-THC by dry weight is generally federally legal as hemp. The limit is the FDA, which has not authorised cannabinoids as foods or dietary supplements, so a lawful hemp derivative can still be an unlawful food ingredient. For a brand weighing a food or supplement format, that second point is the one that bites. Dated 2026-07-11; general information, not legal advice.
It depends on your state. Some restrict hemp cannabinoids more tightly than federal law does, and since statutes almost never name CBDVA, it usually inherits the state's general hemp and THC rules. Check the current statute or ask a qualified attorney. Dated 2026-07-11; informational only, not legal advice.
Generally not as a food or supplement anyone can sell freely. The EU and UK treat extracted cannabinoids as novel foods that need authorisation, CBDVA holds none of its own, and Canada regulates isolated phytocannabinoids under the Cannabis Act. Rules vary by product class and change often, so check the current national position before relying on this. Dated 2026-07-11; general information, not legal advice.
None has been established, and verified human or preclinical evidence of any benefit from CBDVA is missing. The benefit talk usually borrows from its neutral form: CBDV has been explored in outside epilepsy and autism research, but that work concerns CBDV rather than CBDVA, and it has not established efficacy (not medical advice). Catalogue in progress.
CBDVA is used mostly as an ingredient in raw-cannabinoid or full-spectrum products and as a research and reference compound, with no established therapeutic use. Its real job is chemical: it is the acid that becomes CBDV when heated (not medical advice). Catalogue in progress.
No effect in people has been established for CBDVA. The verified data stop at in-vitro observations of the acids, such as DAGLα inhibition (De Petrocellis 2011). Outside research on neutral CBDV, in seizures for example, exists but is unproven and concerns a different molecule (not medical advice), so a seizure claim on a CBDVA label is borrowing from that other molecule. Catalogue in progress.
No. CBDVA itself has never been tested in a controlled human trial, and that is an absence of testing rather than a negative result: with the study still unrun, the ledger for and against it in people is blank, and its human safety and efficacy remain catalogue in progress. CBDV, the decarboxylated form, has been studied and did not establish efficacy, but its record belongs to a different molecule and stays there.
Nobody has established that. CBDVA lacks human safety studies, a defined dose and long-term data, so the accurate word is untested: an open question, and not a clean bill of health. A compound that doesn't get you high has passed one test, and safety is a different one. Consult a qualified professional before use, especially if you take other medications. Catalogue in progress. (Not medical advice.)
CBDVA's side effects are unknown. No controlled study has documented its adverse effects, and a lack of data is no evidence of safety. Products can also carry other cannabinoids or contaminants. If you feel unwell, stop and seek advice (not medical advice). Catalogue in progress.
Nobody can say. Without a defined safe or effective CBDVA dose, or any overdose data, "too much" lacks a benchmark. With any unstudied compound, more is not better. This is not dosing or medical advice. Catalogue in progress.
Interaction data specific to CBDVA are absent. Cannabinoids in general can affect the enzymes that metabolise drugs, so an interaction is plausible for CBDVA, though unverified. If you take any medication, and seizure medication in particular given the research context of CBDV, ask a clinician or pharmacist first (not medical advice). Catalogue in progress.
Probably not. A standard drug test hunts for THC's metabolite (THC-COOH), and CBDVA, which heat turns into CBDV rather than THC, gives it nothing to find, so direct interference is unlikely. The live variable is trace THC in the hemp product itself. Cross-reactivity data for CBDVA specifically are limited, which leaves a current third-party certificate of analysis as the only way to see what a product contains.
No. CBDVA is a different molecule, and heat turns it into non-intoxicating CBDV rather than THC; pure CBDVA contains no THC, as a matter of Established chemistry. The product is what varies. Hemp-derived goods can carry trace Δ⁹-THC unless they are made from isolate, so read the batch certificate of analysis (COA) rather than the front label.
CBDVA itself is an unlikely culprit. Drug tests look elsewhere, and CBDVA forms no THC. The risk sits with trace THC in a hemp product, so anyone who is drug-tested should choose products whose COA shows non-detectable THC.
CBDVA is usually taken in raw or full-spectrum hemp preparations, or as a reference isolate, since heat would turn it into CBDV. It may be used sublingually or in a raw-cannabinoid blend. Those are formats, and the route and dose for CBDVA remain unstudied (not medical advice).
Few, because CBDVA is rare: some raw or full-spectrum extracts, varin-focused blends and reference isolates for laboratories. Standalone consumer CBDVA products are uncommon, and in any heated product the CBDVA will already have become CBDV. Potency and purity swing widely between sellers, so a current third-party certificate of analysis (COA) is the only reliable way to know what the bottle holds.
CBDVA has no established dose. No clinical study has defined a safe or effective amount, so any figure on a label is the manufacturer's choice rather than a number drawn from evidence, and CBG Atlas offers no dosing guidance. Consult a qualified professional (not medical or dosing advice). Catalogue in progress.
Only if you want CBDV. Heat decarboxylates CBDVA and drives off CO₂, and around 130 °C for roughly 30 minutes converts it to CBDV almost completely. Kept raw and cool, CBDVA stays a non-intoxicating acid whose own effects are untested rather than tested and null. Heat reliably delivers the chemical conversion; any benefit from it remains unshown, and that side of the question is catalogue in progress.
One carboxyl group. CBDVA is the raw acid in the plant, and CBDV is the neutral form left once heat has driven that group off as CO₂ (decarboxylation), almost completely at around 130 °C/30 min. Neither intoxicates. Research has paid CBDV somewhat more attention than the acid.
They differ only in side-chain length. CBDVA is the varin (propyl) acid that yields CBDV, and CBDA is the pentyl acid that yields CBD. Both are non-intoxicating cannabinoid acids that decarboxylate when heated, and each becomes its own distinct neutral cannabinoid.
CBDVA, THCVA and CBGVA are the three varin acids, and CBGVA is the mother of the other two, branching into CBDVA (→CBDV) and THCVA (→THCV). Set beside the pentyl acids (CBGA, CBDA, THCA, CBCA), they share the same acid chemistry on propyl side chains two carbons shorter, and all are non-intoxicating in raw form. The family tree is Established; what any of them does in a person is a separate and largely untested question.
Yes, they are different molecules. "Raw" means the acid, CBDVA, is intact and non-intoxicating; "decarbed" means heat has removed its carboxyl group, leaving neutral CBDV. Only decarbed material is CBDV, an Established relationship. Neither form is an approved or established treatment for anything, and CBDVA's own human evidence is catalogue in progress. (Not medical advice.)
CBDVA's formula is C20H26O4, with a molecular weight of ≈ 330.42 g/mol and CAS number 31932-13-5. It is the carboxylic-acid precursor of CBDV (C19H26O2) and the varin analog of CBDA, carrying a carboxyl group that neutral CBDV lacks; heat removes that group as CO₂ and leaves CBDV. The chemical identity is Established. What CBDVA does biologically is a separate, largely unstudied question.
CBDVA is extracted from raw, unheated, varin-rich cannabis with gentle methods that avoid heat, since heat converts it to CBDV, and then purified by chromatography. Plants make very little of it and heat destroys the acid, so isolating stable CBDVA gives low yields and demands real technical care, which goes a long way to explaining why finished CBDVA products are rare. The extraction chemistry is Established.
Yes. CBGVA, the varin mother acid, is the precursor: a synthase enzyme turns it into CBDVA on one branch, the varin twin of the step by which CBGA yields CBDA on the pentyl line. The varin synthases themselves are less well characterised, which leaves that enzymatic step catalogue in progress.
About 130 °C for ~30 minutes gives near-complete conversion, a condition verified directly for this acid. Around 110 °C works more slowly, and hotter settings (150–160 °C) are faster but risk degrading the material. For a processor, 130 °C is the documented reference point.
A handful of specialty hemp, cannabinoid and reference-chemical suppliers carry it, usually as raw-cannabinoid extracts or reference isolates, and stock comes and goes, as it does for any niche product. CBG Atlas endorses no brand. The one filter worth applying is simple: buy only from vendors who publish third-party lab results.
Because only a few plants make it, and heat takes it away. CBDVA occurs in specific varin-rich chemotypes, in small amounts, and heat converts it to CBDV, so isolating a stable supply gives low yields and is technically demanding. Cold handling, cold storage and extra purification all add cost, which is why it sells dear next to common cannabinoids like CBD. Scarcity reflects supply and says nothing about potency.
Get a current certificate of analysis (COA) from an accredited third-party lab and read it against the label. It should confirm the CBDVA content, show the THC level and screen for pesticides, solvents and heavy metals. A missing COA, or one whose numbers disagree with the label, is a red flag.
Your decision. CBDVA has no established benefit and has never been tested in a controlled human trial, so any value is speculative: untested, a different state from tested and rejected. Catalogue in progress. If you try it, choose lab-tested products with a current certificate of analysis and keep your expectations level with the evidence. (Not medical advice.)
A third-party COA that matches the label, a compliant and clearly declared THC level, stated cannabinoid amounts, contaminant screening and transparent sourcing. Treat health claims with suspicion, seizure claims borrowed from CBDV research above all: none is verified for CBDVA, whose evidence file reads catalogue in progress. At the point of sale, testing and transparency are what you can actually check. (Not medical advice.)
Informational only, not medical advice. CBG Atlas is a scientific reference. Nothing here diagnoses, treats, cures or prevents any disease. Every claim on the page carries the grade of the evidence behind it, and the grade sets the words the claim may use. How we grade evidence.
Educational, not medical or legal advice. Statements about effects, benefits or uses report claims made by third parties. CBG Atlas does not make, adopt or affirm them. Legal status depends on jurisdiction, product class and date, and it changes, so check it against the official source. See how we grade and the safety page.
Cardiovascular note. CBG is a potent α2-adrenoceptor agonist in vitro, and α2 agonism can lower blood pressure. Anyone taking blood-pressure or other cardiovascular medication should consult a clinician before use. This is educational information, not medical advice.
Funding and independence. Peregrine Biopharma funds the platform and holds no editorial authority.
Report a safety event →Its acid or neutral form
Head-to-head