New publicationACS Pharmacology & Translational Science · Vol 9 · Issue 10 · pp 2772–2782 ·
CBG and muscle
Cannabigerol Enhances Muscle Strength and Performance in Dexamethasone-Treated Mice
Izabel Feltrin Fabro, Tatyana Nery, Ana Paula Pinto de Araújo and 3 more · open access, CC BY 4.0
study type: Animal · preclinicalNot yet graded
- What they tested
- Mice with muscle wasting caused by a steroid medicine (dexamethasone) did four weeks of resistance training, climbing a ladder with weights, with CBG or without it. Sedentary groups, with and without CBG, served as controls.
- What the authors report
- Mice given CBG while training generated more muscle power than mice that trained alone: about 55% more in the first week and 87% more by the fourth.
- CBG-treated mice also gripped about 10% harder, whether they trained or not.
- Muscle-fibre size changed only modestly, so the gain was in what the muscle could do more than in how big it grew.
- What it cannot tell you
- This is one study, in male mice, with steroid-induced wasting rather than ageing or weight loss. Outcomes were not assessed blind, and how CBG might do this was not tested. It does not show that CBG builds or protects muscle in people; that takes human trials of CBG itself. The authors do cite a human trial on muscle soreness after exercise, but it tested a multi-ingredient formulation containing CBG, so it cannot say what CBG alone does.
Declared interests. One author is a partner in a medical-cannabis company, Remederi, declared in the paper. The work was funded by Brazilian public research agencies (CAPES, FAPESC, CNPq).