Graded claim

CBG and colorectal cancer

What does the evidence show for CBG and colorectal cancer?

In cell and mouse studies, CBG reduced the growth of colorectal-cancer cells and slowed chemically-induced colon-tumor development, an effect linked to TRPM8 blockade. This is strictly preclinical — not tested in humans and not a therapy.

grade: Lowpreclinical only
What reaching the next rung would take

Any one of these, on top of what our registry already holds:

  • one animal (preclinical) effect study from a research group not already counted here
  • one human trial of any size — including a small, short (acute / single-dose) one

The grade weighs the claim as a whole, across every study our registry holds on the question. How good any one of those papers is remains a separate matter, and you can judge each on its own terms.

Permalink

Studies behind this grade

2014

Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid

Borrelli et al. · Carcinogenesis · PMID 25269802 · study type: Animal · preclinical

in vitro + animal (CRC cells; mouse colon cancer models) · animal

PubMed →

One more study on this question is still in intake review. It joins the citations and the grade only if it clears its review.

Other conditions we cover

The CBG monograph covers the compound end to end, and the gap-map charts the questions nobody has tested yet.

CBG acts on α2-adrenoceptors, which help regulate blood pressure; anyone taking cardiovascular medication should consult a clinician before using CBG products. Nothing on this page is medical advice, and no statement here is a claim that CBG treats, cures, or prevents any condition. Grades are based on the studies we had checked as of 9 August 2026. Report a safety event. Peregrine Biopharma funds the platform and holds no editorial authority.