Tested in people, with a null result

CBG for sleep

What does the evidence show for CBG and sleep?

This was tested, and the evidence does not support it. In a randomised, triple-blind, placebo-controlled trial in veterans — 63 randomised, 35 completing without major protocol deviations — CBG at 25 mg daily for two weeks then 50 mg daily for two weeks did not improve sleep quality more than placebo: the primary endpoint was null, and the disability and PTSD-symptom measures showed the same pattern. Scores improved in both arms, which is exactly what a placebo control exists to separate. CBG was well tolerated. The sponsor is a CBG product company (Metta Medical dba LEVEL), and the authors state that no firm conclusion on efficacy for sleep can be made. This is the only randomised placebo-controlled test of a repeated-dose CBG efficacy claim in the registry, and it did not find an effect — an absence of benefit that was measured, not an absence of research.

This was studied in people, and the results do not support it. A null result is a finding in its own right, often the most useful one we can report. The trial behind it is still in intake review and has no graded registry entry yet, so we describe it without a PMID link.

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One more study on this question is still in intake review. It joins the citations and the grade only if it clears its review.

Registered clinical trials on this question

What researchers have attempted is part of the answer, even where the attempt has produced no paper. Registration is not evidence, though, and none of these trials changes the grade above.

2024

A double-blind, randomized, placebo-controlled study of various cannabinoids on sleep quality

Cannabis Science Innovations, LLC · N/A · n=332 · completed · no publication located

Sleep quality — CBG is one of several cannabinoids in each arm; no CBG-only arm.

NCT07769164 →
2022

Swallowable cannabigerol tablets on sleep quality in veterans

Chris Emerson · N/A · n=68 · completed · published

Sleep — Emerson 2025 (PMID 41574318) — published, in intake review, not yet a graded registry entry.

NCT05088018 →

Source: ClinicalTrials.gov, retrieved 2026-08-31. A completed trial marked no publication located is one our search came up empty on, and searches by trial identifier are known to miss papers. So we write “never published” only when we have positive evidence for it.

Other conditions we cover

The CBG monograph covers the compound end to end, and the gap-map charts the questions nobody has tested yet.

CBG acts on α2-adrenoceptors, which help regulate blood pressure; anyone taking cardiovascular medication should consult a clinician before using CBG products. Nothing on this page is medical advice, and no statement here is a claim that CBG treats, cures, or prevents any condition. Grades are based on the studies we had checked as of 9 August 2026. Report a safety event. Peregrine Biopharma funds the platform and holds no editorial authority.